Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice

Traumatic brain injury-induced coagulopathy (TBI-IC) causes life-threatening secondary intracranial bleeding. Its pathogenesis differs mechanistically from that of coagulopathy arising from extracranial injuries and hemorrhagic shock, but it remains poorly understood. We report results of a study de...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Xu, Xin, Wang, Chenyu, Wu, Yingang, Houck, Katie, Hilton, Tristan, Zhou, Ashley, Wu, Xiaoping, Han, Cha, Yang, Mengchen, Yang, Wei, Shi, Fu-Dong, Stolla, Moritz, Cruz, Miguel A., Li, Min, Zhang, Jianning, Dong, Jing-fei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2021
Onderwerpen:
Thrombosis and Hemostasis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845006/
https://ncbi.nlm.nih.gov/pubmed/33507292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007364
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