The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development

The tumor suppressor TP53 can initiate a plethora of anti-proliferative effects to maintain genomic integrity under conditions of genotoxic stress. The N-terminal proline-rich domain (PRD) of TP53 is important in the regulation of TP53 activity and stability. A common polymorphism at codon 72 in thi...

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Pubblicato in:Mol Carcinog
Autori principali: Adams, Cassandra J., Yu, Jennifer S., Mao, Jian-Hua, Jen, Kuang-Yu, Costes, Sylvain V., Wade, Mark, Shoemake, Jocelyn, Aina, Olulanu H., Rosario, Reyno Del, Menchavez, Phuong Thuy, Cardiff, Robert D., Wahl, Geoffrey M., Balmain, Allan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891300/
https://ncbi.nlm.nih.gov/pubmed/26310697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22377
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