Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs

Adeno-associated virus (AAV) vector-based gene therapy is a promising treatment strategy for delivery of neurotrophic transgenes to retinal ganglion cells (RGCs) in glaucoma patients. Retinal distribution of transgene expression following intravitreal injection (IVT) of AAV is variable in animal mod...

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Détails bibliographiques
Publié dans:Gene Ther
Auteurs principaux: Boyd, RF, Boye, SL, Conlon, TJ, Erger, KE, Sledge, DG, Langohr, IM, Hauswirth, WW, Komáromy, AM, Boye, SE, Petersen-Jones, SM, Bartoe, JT
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891289/
https://ncbi.nlm.nih.gov/pubmed/27052802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.31
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