Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs

Adeno-associated virus (AAV) vector-based gene therapy is a promising treatment strategy for delivery of neurotrophic transgenes to retinal ganglion cells (RGCs) in glaucoma patients. Retinal distribution of transgene expression following intravitreal injection (IVT) of AAV is variable in animal mod...

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Detaylı Bibliyografya
Yayımlandı:Gene Ther
Asıl Yazarlar: Boyd, RF, Boye, SL, Conlon, TJ, Erger, KE, Sledge, DG, Langohr, IM, Hauswirth, WW, Komáromy, AM, Boye, SE, Petersen-Jones, SM, Bartoe, JT
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891289/
https://ncbi.nlm.nih.gov/pubmed/27052802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.31
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