Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs

Adeno-associated virus (AAV) vector-based gene therapy is a promising treatment strategy for delivery of neurotrophic transgenes to retinal ganglion cells (RGCs) in glaucoma patients. Retinal distribution of transgene expression following intravitreal injection (IVT) of AAV is variable in animal mod...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Boyd, RF, Boye, SL, Conlon, TJ, Erger, KE, Sledge, DG, Langohr, IM, Hauswirth, WW, Komáromy, AM, Boye, SE, Petersen-Jones, SM, Bartoe, JT
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891289/
https://ncbi.nlm.nih.gov/pubmed/27052802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.31
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