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Phase 1 study of an AKT-inhibitor (MK-2206) combined with lapatinib in adult solid tumors followed by dose-expansion in advanced HER2+ breast cancer
PURPOSE: Preclinical data supports combining AKT-inhibitors with human epidermal growth factor receptor-2 (HER2) targeted therapies to overcome resistance to treatment. This Phase 1 study combined the investigational AKT inhibitor, MK-2206, with lapatinib to determine the maximum tolerated dose (MTD...
Shranjeno v:
| izdano v: | Clin Cancer Res |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891227/ https://ncbi.nlm.nih.gov/pubmed/27026198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2365 |
| Oznake: |
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