ロード中...

Phase 1 study of an AKT-inhibitor (MK-2206) combined with lapatinib in adult solid tumors followed by dose-expansion in advanced HER2+ breast cancer

PURPOSE: Preclinical data supports combining AKT-inhibitors with human epidermal growth factor receptor-2 (HER2) targeted therapies to overcome resistance to treatment. This Phase 1 study combined the investigational AKT inhibitor, MK-2206, with lapatinib to determine the maximum tolerated dose (MTD...

詳細記述

保存先:
書誌詳細
出版年:Clin Cancer Res
主要な著者: Wisinski, Kari B., Tevaarwerk, Amye J., Burkard, Mark E., Rampurwala, Murtuza, Eickhoff, Jens, Bell, Maria, Kolesar, Jill M., Flynn, Christopher, Liu, Glenn
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891227/
https://ncbi.nlm.nih.gov/pubmed/27026198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2365
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!