Phase 1b study of orteronel in postmenopausal women with hormone-receptor positive (HR+) metastatic breast cancer

INTRO: Suppressing both androgens and estrogens may circumvent hormone receptor resistance in breast cancer by reducing androgen receptor stimulation. Selective inhibition of the 17, 20-lyase enzyme by orteronel leads to decreased androgen production in men and would be anticipated to reduce estroge...

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Bibliografische gegevens
Gepubliceerd in:Invest New Drugs
Hoofdauteurs: Rampurwala, Murtuza, Wisinski, Kari B, Burkard, Mark E, Ehsani, Sima, O’Regan, Ruth M, Carmichael, Lakeesha, Kim, KyungMann, Kolesar, Jill, Tevaarwerk, Amye J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590750/
https://ncbi.nlm.nih.gov/pubmed/27826831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-016-0403-2
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