Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer

PURPOSE: We tested the hypothesis that allosteric Akt inhibitor MK-2206 inhibits tumor growth, and that PTEN/PIK3CA mutations confer MK-2206 sensitivity. EXPERIMENTAL DESIGN: MK-2206 effects on cell signaling were assessed in vitro and in vivo. Its antitumor efficacy was assessed in vitro in a panel...

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Autori principali: Sangai, Takafumi, Akcakanat, Argun, Chen, Huiqin, Tarco, Emily, Wu, Yun, Do, Kim-Anh, Miller, Todd W., Arteaga, Carlos L., Mills, Gordon B., Gonzalez-Angulo, Ana Maria, Meric-Bernstam, Funda
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772348/
https://ncbi.nlm.nih.gov/pubmed/22932669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1141
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