Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways

Zoledronate is a standard treatment for preventing skeletal complications of osteoporosis and some types of cancer associated with bone metastases, but we little know whether the effect of zoledronate on metastasis of osteosarcoma. Here, we investigated the inhibitory effects of zoledronate on cell...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Cheng, Hsin-Lin, Lin, Chiao-Wen, Yang, Jia-Sin, Hsieh, Ming-Ju, Yang, Shun-Fa, Lu, Ko-Hsiu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891081/
https://ncbi.nlm.nih.gov/pubmed/26848867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7138
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