Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways

Zoledronate is a standard treatment for preventing skeletal complications of osteoporosis and some types of cancer associated with bone metastases, but we little know whether the effect of zoledronate on metastasis of osteosarcoma. Here, we investigated the inhibitory effects of zoledronate on cell...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Cheng, Hsin-Lin, Lin, Chiao-Wen, Yang, Jia-Sin, Hsieh, Ming-Ju, Yang, Shun-Fa, Lu, Ko-Hsiu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891081/
https://ncbi.nlm.nih.gov/pubmed/26848867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7138
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