The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma

Deregulation of mTOR and IGF pathways is frequent in hepatocellular carcinoma (HCC), thus mTOR and IGF1R represent suitable therapeutic targets in HCC. The aim of this study was to evaluate the effects of mTOR inhibitors (mTORi) and OSI-906, blocker of IGF1R/IR, on HCC cell proliferation, viability,...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Pivonello, Claudia, Negri, Mariarosaria, De Martino, Maria Cristina, Napolitano, Maria, de Angelis, Cristina, Provvisiero, Donatella Paola, Cuomo, Gaia, Auriemma, Renata Simona, Simeoli, Chiara, Izzo, Francesco, Colao, Annamaria, Hofland, Leo J., Pivonello, Rosario
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891079/
https://ncbi.nlm.nih.gov/pubmed/26756219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6836
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