Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit

Primary or acquired resistant mechanisms prevent the employment of individualized therapy with target drugs like the mTOR inhibitor everolimus (EVE) in hepatocellular carcinoma (HCC). The current study evaluated the effect of 1,25(OH)(2)Vitamin D (VitD) treatment on EVE sensitivity in established mo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Provvisiero, Donatella Paola, Negri, Mariarosaria, de Angelis, Cristina, Di Gennaro, Gilda, Patalano, Roberta, Simeoli, Chiara, Papa, Fortuna, Ferrigno, Rosario, Auriemma, Renata Simona, De Martino, Maria Cristina, Colao, Annamaria, Pivonello, Rosario, Pivonello, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690984/
https://ncbi.nlm.nih.gov/pubmed/31406139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48081-9
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