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Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit
Primary or acquired resistant mechanisms prevent the employment of individualized therapy with target drugs like the mTOR inhibitor everolimus (EVE) in hepatocellular carcinoma (HCC). The current study evaluated the effect of 1,25(OH)(2)Vitamin D (VitD) treatment on EVE sensitivity in established mo...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6690984/ https://ncbi.nlm.nih.gov/pubmed/31406139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48081-9 |
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