The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma

Deregulation of mTOR and IGF pathways is frequent in hepatocellular carcinoma (HCC), thus mTOR and IGF1R represent suitable therapeutic targets in HCC. The aim of this study was to evaluate the effects of mTOR inhibitors (mTORi) and OSI-906, blocker of IGF1R/IR, on HCC cell proliferation, viability,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pivonello, Claudia, Negri, Mariarosaria, De Martino, Maria Cristina, Napolitano, Maria, de Angelis, Cristina, Provvisiero, Donatella Paola, Cuomo, Gaia, Auriemma, Renata Simona, Simeoli, Chiara, Izzo, Francesco, Colao, Annamaria, Hofland, Leo J., Pivonello, Rosario
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891079/
https://ncbi.nlm.nih.gov/pubmed/26756219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6836
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