The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma

Deregulation of mTOR and IGF pathways is frequent in hepatocellular carcinoma (HCC), thus mTOR and IGF1R represent suitable therapeutic targets in HCC. The aim of this study was to evaluate the effects of mTOR inhibitors (mTORi) and OSI-906, blocker of IGF1R/IR, on HCC cell proliferation, viability,...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Pivonello, Claudia, Negri, Mariarosaria, De Martino, Maria Cristina, Napolitano, Maria, de Angelis, Cristina, Provvisiero, Donatella Paola, Cuomo, Gaia, Auriemma, Renata Simona, Simeoli, Chiara, Izzo, Francesco, Colao, Annamaria, Hofland, Leo J., Pivonello, Rosario
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891079/
https://ncbi.nlm.nih.gov/pubmed/26756219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6836
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