The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma

Deregulation of mTOR and IGF pathways is frequent in hepatocellular carcinoma (HCC), thus mTOR and IGF1R represent suitable therapeutic targets in HCC. The aim of this study was to evaluate the effects of mTOR inhibitors (mTORi) and OSI-906, blocker of IGF1R/IR, on HCC cell proliferation, viability,...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Pivonello, Claudia, Negri, Mariarosaria, De Martino, Maria Cristina, Napolitano, Maria, de Angelis, Cristina, Provvisiero, Donatella Paola, Cuomo, Gaia, Auriemma, Renata Simona, Simeoli, Chiara, Izzo, Francesco, Colao, Annamaria, Hofland, Leo J., Pivonello, Rosario
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891079/
https://ncbi.nlm.nih.gov/pubmed/26756219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6836
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker