Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2-overexpressing cancer cells

The therapeutic potential of RNA interference (RNAi) has been limited by inefficient delivery of short interfering RNA (siRNA). Tumor-specific recognition can be effectively achieved by antibodies directed against highly expressed cancer cell surface receptors. We investigated the utility of linking...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Palanca-Wessels, Maria C., Booth, Garrett C., Convertine, Anthony J., Lundy, Brittany B., Berguig, Geoffrey Y., Press, Michael F., Stayton, Patrick S., Press, Oliver W.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891060/
https://ncbi.nlm.nih.gov/pubmed/26840082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7076
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