Anti-CD22 Antibody Targeting of pH-responsive Micelles Enhances Small Interfering RNA Delivery and Gene Silencing in Lymphoma Cells

The application of small interfering RNA (siRNA) for cancer treatment is a promising strategy currently being explored in early phase clinical trials. However, efficient systemic delivery limits clinical implementation. We developed and tested a novel delivery system comprised of (i) an internalizin...

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Detalhes bibliográficos
Main Authors: Palanca-Wessels, Maria C, Convertine, Anthony J, Cutler-Strom, Richelle, Booth, Garrett C, Lee, Fan, Berguig, Geoffrey Y, Stayton, Patrick S, Press, Oliver W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149160/
https://ncbi.nlm.nih.gov/pubmed/21629223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.104
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