microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis

The tumor suppressor p53 plays a central role in tumor prevention. The E3 ubiquitin ligase MDM2 is the most critical negative regulator of p53, which binds to p53 and degrades p53 through ubiquitation. MDM2 itself is a transcriptional target of p53, and therefore, MDM2 forms a negative feedback loop...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Zhang, Cen, Liu, Juan, Tan, Chunwen, Yue, Xuetian, Zhao, Yuhan, Peng, Jiaping, Wang, Xiaolong, Laddha, Saurabh V., Chan, Chang S., Zheng, Shu, Hu, Wenwei, Feng, Zhaohui
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891004/
https://ncbi.nlm.nih.gov/pubmed/26840028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7088
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