Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells

Bacterial lipopolysaccharide (LPS) induces release of inflammatory mediators both in immune and epithelial cells. We investigated whether changes of epigenetic marks, including selected histone modification and DNA methylation, may drive or accompany the activation of COX-2 gene in HT-29 human intes...

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Pubblicato in:PLoS One
Autori principali: Angrisano, Tiziana, Pero, Raffaela, Brancaccio, Mariarita, Coretti, Lorena, Florio, Ermanno, Pezone, Antonio, Calabrò, Viola, Falco, Geppino, Keller, Simona, Lembo, Francesca, Avvedimento, Vittorio Enrico, Chiariotti, Lorenzo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890762/
https://ncbi.nlm.nih.gov/pubmed/27253528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156671
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