The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence

Decreased Na(+), K(+)-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β, and γ, with four distinct isoforms of the catalytic α subunit (α(1−4)). Genetic mutations in the ATP1A2 gene and ATP1A3 gene...

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Publicat a:Front Physiol
Autors principals: Kinoshita, Paula F., Leite, Jacqueline A., Orellana, Ana Maria M., Vasconcelos, Andrea R., Quintas, Luis E. M., Kawamoto, Elisa M., Scavone, Cristoforo
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890531/
https://ncbi.nlm.nih.gov/pubmed/27313535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00195
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