Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication

Nitazoxanide (Alinia(®), NTZ) and tizoxanide (TIZ), its active circulating metabolite, belong to a class of agents known as thiazolides (TZD) endowed with broad anti-infective activities. TIZ and RM-4848, the active metabolite of RM-5038, were shown to stimulate innate immunity in vitro. Because nat...

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Publicat a:Sci Rep
Autors principals: Trabattoni, Daria, Gnudi, Federica, Ibba, Salomè V., Saulle, Irma, Agostini, Simone, Masetti, Michela, Biasin, Mara, Rossignol, Jean-Francois, Clerici, Mario
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890011/
https://ncbi.nlm.nih.gov/pubmed/27250526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27148
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