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Enhancing protein stability with extended disulfide bonds

Disulfide bonds play an important role in protein folding and stability. However, the cross-linking of sites within proteins by cysteine disulfides has significant distance and dihedral angle constraints. Here we report the genetic encoding of noncanonical amino acids containing long side-chain thio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Tao, Wang, Yan, Luo, Xiaozhou, Li, Jack, Reed, Sean A., Xiao, Han, Young, Travis S., Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889405/
https://ncbi.nlm.nih.gov/pubmed/27162342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605363113
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