Interactions between RNA polymerase and the core recognition element are a determinant of transcription start site selection

During transcription initiation, RNA polymerase (RNAP) holoenzyme unwinds ∼13 bp of promoter DNA, forming an RNAP-promoter open complex (RPo) containing a single-stranded transcription bubble, and selects a template-strand nucleotide to serve as the transcription start site (TSS). In RPo, RNAP core...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Vvedenskaya, Irina O., Vahedian-Movahed, Hanif, Zhang, Yuanchao, Taylor, Deanne M., Ebright, Richard H., Nickels, Bryce E.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889395/
https://ncbi.nlm.nih.gov/pubmed/27162333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603271113
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