Multiplexed protein-DNA crosslinking: scrunching in transcription start site selection

In bacterial transcription initiation, RNA polymerase (RNAP) selects a transcription start site (TSS) at variable distances downstream of core promoter elements. Using next-generation sequencing and unnatural-amino-acid-mediated protein-DNA crosslinking, we have determined, for a library of 4(10) pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Winkelman, Jared T., Vvedenskaya, Irina O., Zhang, Yuanchao, Zhang, Yu, Bird, Jeremy G., Taylor, Deanne M., Gourse, Richard L., Ebright, Richard H., Nickels, Bryce E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797950/
https://ncbi.nlm.nih.gov/pubmed/26941320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6881
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