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Multiplexed protein-DNA crosslinking: scrunching in transcription start site selection
In bacterial transcription initiation, RNA polymerase (RNAP) selects a transcription start site (TSS) at variable distances downstream of core promoter elements. Using next-generation sequencing and unnatural-amino-acid-mediated protein-DNA crosslinking, we have determined, for a library of 4(10) pr...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4797950/ https://ncbi.nlm.nih.gov/pubmed/26941320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6881 |
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