Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts

Nephrogenic diabetes insipidus (NDI) is characterized by production of very large quantities of dilute urine due to an inability of the kidney to respond to vasopressin. Congenital NDI results from mutations in the type 2 vasopressin receptor (V(2)R) in ∼90% of families. These patients do not have m...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Klein, Janet D., Wang, Yanhua, Blount, Mitsi A., Molina, Patrick A., LaRocque, Lauren M., Ruiz, Joseph A., Sands, Jeff M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Rapid Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889320/
https://ncbi.nlm.nih.gov/pubmed/26962099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00102.2016
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