Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts

Nephrogenic diabetes insipidus (NDI) is characterized by production of very large quantities of dilute urine due to an inability of the kidney to respond to vasopressin. Congenital NDI results from mutations in the type 2 vasopressin receptor (V(2)R) in ∼90% of families. These patients do not have m...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Klein, Janet D., Wang, Yanhua, Blount, Mitsi A., Molina, Patrick A., LaRocque, Lauren M., Ruiz, Joseph A., Sands, Jeff M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
Schlagworte:
Rapid Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889320/
https://ncbi.nlm.nih.gov/pubmed/26962099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00102.2016
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