Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects

Alterations in O-GlcNAc cycling, the addition and removal of O-GlcNAc, lead to mitotic defects and increased aneuploidy. Herein, we generated stable O-GlcNAcase (OGA, the enzyme that removes O-GlcNAc) knockdown HeLa cell lines and characterized the effect of the reduction in OGA activity on cell cyc...

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Lanza, Chris, Tan, Ee Phie, Zhang, Zhen, Machacek, Miranda, Brinker, Amanda E., Azuma, Mizuki, Slawson, Chad
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889296/
https://ncbi.nlm.nih.gov/pubmed/27070276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1167297
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