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Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects
Alterations in O-GlcNAc cycling, the addition and removal of O-GlcNAc, lead to mitotic defects and increased aneuploidy. Herein, we generated stable O-GlcNAcase (OGA, the enzyme that removes O-GlcNAc) knockdown HeLa cell lines and characterized the effect of the reduction in OGA activity on cell cyc...
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| Опубликовано в: : | Cell Cycle |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889296/ https://ncbi.nlm.nih.gov/pubmed/27070276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1167297 |
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