Structure of the human dimeric ATM kinase

DNA-double strand breaks activate the serine/threonine protein kinase ataxia-telangiectasia mutated (ATM) to initiate DNA damage signal transduction. This activation process involves autophosphorylation and dissociation of inert ATM dimers into monomers that are catalytically active. Using single-pa...

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Lau, Wilson C. Y., Li, Yinyin, Liu, Zhe, Gao, Yuanzhu, Zhang, Qinfen, Huen, Michael S. Y.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889239/
https://ncbi.nlm.nih.gov/pubmed/27097373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1158362
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