Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial homeostasis. Perturbation of mitochondria during la...

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發表在:Cell
Main Authors: Merkwirth, Carsten, Jovaisaite, Virginija, Durieux, Jenni, Matilainen, Olli, Jordan, Sabine D., Quiros, Pedro M., Steffen, Kristan K., Williams, Evan G., Mouchiroud, Laurent, Uhlein, Sarah N., Murillo, Virginia, Wolff, Suzanne C., Shaw, Reuben J., Auwerx, Johan, Dillin, Andrew
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889222/
https://ncbi.nlm.nih.gov/pubmed/27133168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.012
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