Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms

Study of the exacerbating effects of chemotherapeutics, such as doxorubicin, on the impairment of insulin metabolic signaling in aged skeletal muscle is very limited. Here, we tested the hypothesis that activation of sirtuin 1 deacetylase activity by resveratrol would prevent the disruption of insul...

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Detalhes bibliográficos
Publicado no:J Gerontol A Biol Sci Med Sci
Main Authors: Sin, Thomas K., Tam, Bjorn T., Yu, Angus P., Yip, Shea P., Yung, Benjamin Y., Chan, Lawrence W., Wong, Cesar S., Rudd, John A., Siu, Parco M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888387/
https://ncbi.nlm.nih.gov/pubmed/26450947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glv175
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