Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart

Elevations of cardiomyocyte apoptosis and fibrotic deposition are major characteristics of the ageing heart. Resveratrol, a polyphenol in grapes and red wine, is known to improve insulin resistance and increase mitochondrial biogenesis through the SIRT1–PGC-1α signalling axis. Recent studies attempt...

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Detalhes bibliográficos
Main Authors: Sin, Thomas K, Yu, Angus P, Yung, Benjamin Y, Yip, Shea Ping, Chan, Lawrence W, Wong, Cesar S, Ying, Michael, Rudd, John A, Siu, Parco M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080936/
https://ncbi.nlm.nih.gov/pubmed/24639483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.271387
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