A novel class of piperidones exhibit potent, selective and pro-apoptotic anti-leukemia properties

In the present pre-clinical study, a series of 1-[3-(2-methoxyethylthio)-propionyl]-3,5- bis(benzylidene)-4 piperidones and structurally-related compounds were observed to be cytotoxic in vitro to three human leukemia cell lines, namely Nalm-6, CEM and Jurkat. The 50% cytotoxic concentration (CC(50)...

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Detalhes bibliográficos
Publicado no:Oncol Lett
Main Authors: NUNES, LARISSA M, HOSSAIN, MOHAMMAD, VARELA-RAMIREZ, ARMANDO, DAS, UMASHANKAR, AYALA-MARIN, YOSHIRA M, DIMMOCK, JONATHAN R, AGUILERA, RENATO J
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888252/
https://ncbi.nlm.nih.gov/pubmed/27313705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2016.4480
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