Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

BACKGROUND: NLRP3 inflammasome has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The activation of NLRP3 inflammasome results in the production of IL-1β and the subsequent inflammation. Anti-dsDNA antibodies (anti-dsDNA Abs) play critical roles in the development and pro...

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Dades bibliogràfiques
Publicat a:J Transl Med
Autors principals: Zhang, Hui, Fu, Rong, Guo, Chaohuan, Huang, Yuefang, Wang, Hongyue, Wang, Shuang, Zhao, Jijun, Yang, Niansheng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888250/
https://ncbi.nlm.nih.gov/pubmed/27250627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0911-z
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