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Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome

NLRP3 inflammasome is engaged in the inflammatory response during acute lung injury (ALI). Purinergic receptor P2X7 has been reported to be upstream of NLRP3 activation. However, the therapeutic implication of P2X7 in ALI remains to be explored. The present study used lipopolysaccharide (LPS)-induce...

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Detalhes bibliográficos
Publicado no:Int Immunopharmacol
Main Authors: Wang, Shuang, Zhao, Jijun, Wang, Hongyue, Liang, Yingjie, Yang, Niansheng, Huang, Yuefang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185518/
https://ncbi.nlm.nih.gov/pubmed/25937482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2015.04.035
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