Pathogenesis of Lupus Nephritis: RIP3 Dependent Necroptosis and NLRP3 Inflammasome Activation

RIP3 activation leads to activation of necroptosis and the NLRP3 inflammasome pathways. The activation of RIP3 in lupus nephritis (LN) has not been investigated. In this study, RIP3 and necroptosis pathway activations were demonstrated in podocytes in renal biopsies from patients with class IV LN an...

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Bibliographic Details
Published in:J Autoimmun
Main Authors: Guo, Chaohuan, Fu, Rong, Zhou, Mianjing, Wang, Shuang, Huang, Yuefang, Hu, Haoqiang, Zhao, Jijun, Gaskin, Felicia, Yang, Niansheng, Fu, Shu Man
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708470/
https://ncbi.nlm.nih.gov/pubmed/31133359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2019.05.014
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