Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome

NLRP3 inflammasome is engaged in the inflammatory response during acute lung injury (ALI). Purinergic receptor P2X7 has been reported to be upstream of NLRP3 activation. However, the therapeutic implication of P2X7 in ALI remains to be explored. The present study used lipopolysaccharide (LPS)-induce...

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Vydáno v:Int Immunopharmacol
Hlavní autoři: Wang, Shuang, Zhao, Jijun, Wang, Hongyue, Liang, Yingjie, Yang, Niansheng, Huang, Yuefang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier B.V. 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185518/
https://ncbi.nlm.nih.gov/pubmed/25937482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2015.04.035
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