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Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphoedema model

Lymphatic vasculature critically depends on the connections of lymphatic endothelial cells with the extracellular matrix (ECM), which are mediated by anchoring filaments (AFs). The ECM protein EMILIN1 is a component of AFs and is involved in the regulation of lymphatic vessel functions: accordingly,...

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Detalhes bibliográficos
Publicado no:Clin Sci (Lond)
Main Authors: Pivetta, Eliana, Wassermann, Bruna, Belluz, Lisa Del Bel, Danussi, Carla, Modica, Teresa Maria Elisa, Maiorani, Orlando, Bosisio, Giulia, Boccardo, Francesco, Canzonieri, Vincenzo, Colombatti, Alfonso, Spessotto, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888021/
https://ncbi.nlm.nih.gov/pubmed/26920215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20160064
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