Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and VEGFD are proteolytically cleaved after cell secretion in vitro, and recent studies have implicated the protease a disintegrin and metalloprotein...

詳細記述

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書誌詳細
出版年:J Clin Invest
主要な著者: Bui, Hung M., Enis, David, Robciuc, Marius R., Nurmi, Harri J., Cohen, Jennifer, Chen, Mei, Yang, Yiqing, Dhillon, Veerpal, Johnson, Kathy, Zhang, Hong, Kirkpatrick, Robert, Traxler, Elizabeth, Anisimov, Andrey, Alitalo, Kari, Kahn, Mark L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2016
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887177/
https://ncbi.nlm.nih.gov/pubmed/27159393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83967
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