Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and VEGFD are proteolytically cleaved after cell secretion in vitro, and recent studies have implicated the protease a disintegrin and metalloprotein...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Bui, Hung M., Enis, David, Robciuc, Marius R., Nurmi, Harri J., Cohen, Jennifer, Chen, Mei, Yang, Yiqing, Dhillon, Veerpal, Johnson, Kathy, Zhang, Hong, Kirkpatrick, Robert, Traxler, Elizabeth, Anisimov, Andrey, Alitalo, Kari, Kahn, Mark L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887177/
https://ncbi.nlm.nih.gov/pubmed/27159393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83967
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker