Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and VEGFD are proteolytically cleaved after cell secretion in vitro, and recent studies have implicated the protease a disintegrin and metalloprotein...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Bui, Hung M., Enis, David, Robciuc, Marius R., Nurmi, Harri J., Cohen, Jennifer, Chen, Mei, Yang, Yiqing, Dhillon, Veerpal, Johnson, Kathy, Zhang, Hong, Kirkpatrick, Robert, Traxler, Elizabeth, Anisimov, Andrey, Alitalo, Kari, Kahn, Mark L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887177/
https://ncbi.nlm.nih.gov/pubmed/27159393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83967
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