Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and VEGFD are proteolytically cleaved after cell secretion in vitro, and recent studies have implicated the protease a disintegrin and metalloprotein...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bui, Hung M., Enis, David, Robciuc, Marius R., Nurmi, Harri J., Cohen, Jennifer, Chen, Mei, Yang, Yiqing, Dhillon, Veerpal, Johnson, Kathy, Zhang, Hong, Kirkpatrick, Robert, Traxler, Elizabeth, Anisimov, Andrey, Alitalo, Kari, Kahn, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887177/
https://ncbi.nlm.nih.gov/pubmed/27159393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83967
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