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Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model
Homocystinuria, which typically results from cystathionine β-synthase (CBS) deficiency, is the most common defect of sulfur amino acid metabolism. CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine. Individuals with homocystinuria have markedly elevated plasma...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887166/ https://ncbi.nlm.nih.gov/pubmed/27183385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85396 |
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