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Palladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols

An efficient palladium-catalyzed direct arylation of pyridylmethyl silyl ethers with aryl bromides is described. A Pd(OAc)(2)/NIXANTPHOS-based catalyst provides aryl(pyridyl)-methyl alcohol derivatives in good to excellent yields (33 examples, 57–100% yield). This protocol is compatible with differe...

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Bibliografische gegevens
Gepubliceerd in:Org Lett
Hoofdauteurs: Rivero, Alexandra R., Kim, Byeong-Seon, Walsh, Patrick J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887141/
https://ncbi.nlm.nih.gov/pubmed/27004592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b00450
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