Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification

Iron is essential for living organisms and the disturbance of iron homeostasis is associated with altered immune function. Additionally, bacterial infections can cause major complications in instances of chronic iron overload, such as patients with transfusion-dependent thalassemia. Monocytes and ma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kao, Jun-Kai, Wang, Shih-Chung, Ho, Li-Wei, Huang, Shi-Wei, Chang, Shu-Hao, Yang, Rei-Cheng, Ke, Yu-Yuan, Wu, Chun-Ying, Wang, Jiu-Yao, Shieh, Jeng-Jer
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886970/
https://ncbi.nlm.nih.gov/pubmed/27244448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156713
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