TPL‐2 kinase induces phagosome acidification to promote macrophage killing of bacteria

Tumour progression locus 2 (TPL‐2) kinase mediates Toll‐like receptor (TLR) activation of ERK1/2 and p38α MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase‐independent regulatory function for TPL‐2 in phagosome maturatio...

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Publicado no:EMBO J
Main Authors: Breyer, Felix, Härtlova, Anetta, Thurston, Teresa, Flynn, Helen R, Chakravarty, Probir, Janzen, Julia, Peltier, Julien, Heunis, Tiaan, Snijders, Ambrosius P, Trost, Matthias, Ley, Steven C
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126920/
https://ncbi.nlm.nih.gov/pubmed/33881780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106188
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