Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation

Activation of the inducible caspase 9 (iC9) safety gene by a dimerizing drug (chemical inducer of dimerization (CID) AP1903) effectively resolves the symptoms and signs of graft-versus-host disease (GvHD) in haploidentical stem cell transplant (HSCT) recipients. However, after CID treatment, 1% of i...

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Publicat a:Mol Ther
Autors principals: Zhou, Xiaoou, Naik, Swati, Dakhova, Olga, Dotti, Gianpietro, Heslop, Helen E., Brenner, Malcolm K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886936/
https://ncbi.nlm.nih.gov/pubmed/26708005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.234
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