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Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth

Spread of oncolytic viruses through tumor tissue is essential to effective virotherapy. Interstitial matrix is thought to be a significant barrier to virus particle convection between “islands” of tumor cells. One way to address this is to encode matrix-degrading enzymes within oncolytic viruses, fo...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Tedcastle, Alison, Illingworth, Sam, Brown, Alice, Seymour, Leonard W, Fisher, Kerry D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886935/
https://ncbi.nlm.nih.gov/pubmed/26708004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.233
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