Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators

Enadenotucirev (EnAd) is a chimeric group B adenovirus isolated by bioselection from a library of adenovirus serotypes. It replicates selectively in and kills a diverse range of carcinoma cells, shows effective anticancer activity in preclinical systems, and is currently undergoing phase I/II clinic...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Dyer, Arthur, Di, Ying, Calderon, Hugo, Illingworth, Sam, Kueberuwa, Gray, Tedcastle, Alison, Jakeman, Phil, Chia, Suet Lin, Brown, Alice, Silva, Michael A., Barlow, David, Beadle, John, Hermiston, Terry, Ferguson, David J.P., Champion, Brian, Fisher, Kerry D., Seymour, Leonard W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363721/
https://ncbi.nlm.nih.gov/pubmed/28345021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2016.11.003
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