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Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth
Spread of oncolytic viruses through tumor tissue is essential to effective virotherapy. Interstitial matrix is thought to be a significant barrier to virus particle convection between “islands” of tumor cells. One way to address this is to encode matrix-degrading enzymes within oncolytic viruses, fo...
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| Publicado no: | Mol Ther |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4886935/ https://ncbi.nlm.nih.gov/pubmed/26708004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.233 |
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