Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus

Flavivirus nonstructural protein 2B (NS2B) is a transmembrane protein that functions as a cofactor for viral NS3 protease. The cytoplasmic region (amino acids 51 to 95) alone of NS2B is sufficient for NS3 protease activity, whereas the role of transmembrane domains (TMDs) remains obscure. Here, we d...

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Udgivet i:J Virol
Main Authors: Li, Xiao-Dan, Deng, Cheng-Lin, Ye, Han-Qing, Zhang, Hong-Lei, Zhang, Qiu-Yan, Chen, Dong-Dong, Zhang, Pan-Tao, Shi, Pei-Yong, Yuan, Zhi-Ming, Zhang, Bo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886793/
https://ncbi.nlm.nih.gov/pubmed/27053551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00340-16
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