Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74

The viral capsid of HIV-1 interacts with a number of host factors to orchestrate uncoating and regulate downstream events, such as reverse transcription, nuclear entry, and integration site targeting. PF-3450074 (PF74), an HIV-1 capsid-targeting low-molecular-weight antiviral compound, directly bind...

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Bibliographic Details
Published in:J Virol
Main Authors: Saito, Akatsuki, Ferhadian, Damien, Sowd, Gregory A., Serrao, Erik, Shi, Jiong, Halambage, Upul D., Teng, Samantha, Soto, Juan, Siddiqui, Mohammad Adnan, Engelman, Alan N., Aiken, Christopher, Yamashita, Masahiro
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886767/
https://ncbi.nlm.nih.gov/pubmed/27076642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03116-15
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