Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo

Cleavage and polyadenylation specificity factor subunit 6 (CPSF6), a host factor that interacts with the HIV-1 capsid (CA) protein, is implicated in diverse functions during the early part of the HIV-1 life cycle, including uncoating, nuclear entry, and integration targeting. Preservation of CA bind...

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Udgivet i:J Virol
Main Authors: Saito, Akatsuki, Henning, Matthew S., Serrao, Erik, Dubose, Brittany N., Teng, Samantha, Huang, Jing, Li, Xiangming, Saito, Namiko, Roy, Saumendra Prasad, Siddiqui, Mohammad Adnan, Ahn, Jinwoo, Tsuji, Moriya, Hatziioannou, Theodora, Engelman, Alan N., Yamashita, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944271/
https://ncbi.nlm.nih.gov/pubmed/27307565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00019-16
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