Proteasome activity is required for the initiation of precancerous pancreatic lesions

Proteasome activity is significantly increased in advanced cancers, but its role in cancer initiation is not clear, due to difficulties in monitoring this process in vivo. We established a line of transgenic mice that carried the ZsGreen-degron(ODC) (Gdeg) proteasome reporter to monitor the proteaso...

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Pubblicato in:Sci Rep
Autori principali: Furuyama, Takaki, Tanaka, Shinji, Shimada, Shu, Akiyama, Yoshimitsu, Matsumura, Satoshi, Mitsunori, Yusuke, Aihara, Arihiro, Ban, Daisuke, Ochiai, Takanori, Kudo, Atsushi, Fukamachi, Hiroshi, Arii, Shigeki, Kawaguchi, Yoshiya, Tanabe, Minoru
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886684/
https://ncbi.nlm.nih.gov/pubmed/27244456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27044
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